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From inhibition to destruction: Kinase drugs found to trigger protein degradation

August 3, 2023 | Phys.org AI
From inhibition to destruction: Kinase drugs found to trigger protein degradation
Kinase Degradation (KinDeg) map across 1,570 monovalent kinase-targeting compounds. Credit: bioRxiv: DOI: 10.1101/2024.07.10.602881 Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins. When these switches are stuck in the "on" position, they can drive cancer and other diseases. Not surprisingly, kinases have become one of the most important drug t