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From fragments to function: Computer-based design for custom proteins

June 20, 2025 | Phys.org AI
From fragments to function: Computer-based design for custom proteins
Helical shape of a protein. Credit: IBC - TU Graz In the ERC project HelixMold, a team from TU Graz developed a method for the computer-based design of artificial proteins, with a focus on custom biocatalysts for pharmaceutical applications or the degradation of biopolymers. "Imagine a future in which you can design enzymes—nature's catalysts—for your specific application at the push of a button," says Gustav Oberdorfer, who headed the ERC Starting Grant p