Qualitative and quantitative assessment of CELTIC’s contribution to the in silico labeling of rare cell populations. Credit: Nature Methods (2025). DOI: 10.1038/s41592-025-02960-4 To ensure our bodies function correctly, the cells that compose them must operate properly. Imagine a cell as a bustling city where tiny parts called organelles move, reorganize, and respond to external stresses. To understand how our bodies stay healthy, or what goes wrong durin